In Silico Partitioning and Transmembrane Insertion of Hydrophobic Peptides under Equilibrium Conditions
نویسندگان
چکیده
منابع مشابه
Roles of carboxyl groups in the transmembrane insertion of peptides.
We have used pHLIP® [pH (low) insertion peptide] to study the roles of carboxyl groups in transmembrane (TM) peptide insertion. pHLIP binds to the surface of a lipid bilayer as a disordered peptide at neutral pH; when the pH is lowered, it inserts across the membrane to form a TM helix. Peptide insertion is reversed when the pH is raised above the characteristic pK(a) (6.0). A key event that fa...
متن کاملIn silico prediction of anticancer peptides by TRAINER tool
Cancer is one of the causes of death in the world. Several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. Since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. Antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...
متن کاملMethods for studying transmembrane peptides in bicelles: consequences of hydrophobic mismatch and peptide sequence.
We have shown that bicelles prepared from dilauryl phosphatidylcholine (DLPC) and dipalmitoyl phosphatidylcholine (DPPC) align in a magnetic field under conditions similar to the more common dimyristoyl phosphatidylcholine (DMPC) bicelles. In addition, a model transmembrane peptide, P16, with a hydrophobic stretch of 24 A, and specific alanine-d(3) labels, was incorporated into all of the diffe...
متن کاملTransmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications.
We have shown previously that peroxynitrite-induced nitration of a hydrophobic tyrosyl probe is greater than that of tyrosine in the aqueous phase (Zhang, H., Joseph, J., Feix, J., Hogg, N., and Kalyanaraman, B. (2001) Biochemistry 40, 7675-7686). In this study, we have tested the hypothesis that the extent of tyrosine nitration depends on the intramembrane location of tyrosyl probes and on the...
متن کاملApatite-Melt Volatile Partitioning Under Lunar Conditions
Introduction: The volatile component of apatite [Ca5(PO4)3(F,Cl,OH)] makes it a popular choice for studying the abundance and distribution of indigenous lunar volatiles [e.g. 1-5]. The thermodynamic behavior of volatile partitioning into apatite is, however, poorly constrained. Limited experimental studies of apatite/melt partitioning have focused on terrestrial systems [6], chlorine-brine syst...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2011
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja204042f